Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 68292190 | HCID 68292190 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 68359225 | HCID 68359225 | — |
Reaction Steps
A mixture of C-(4-bromophenyl)-N-(2,4-dimethoxybenzyl)methanesulfonamide (1 g), morpholine (0.3 ml), Pd2(dba)3 (51 mg) and cesium carbonate (1.3 g) in dioxane was stirred at 80° C. for 16 h. The mixture was diluted with ethyl acetate, washed with water, dried over magnesium sulfate and concentrated. This was followed by purification by column chromatography (ethyl acetate/heptane). This gave the product (267 mg) with a molecular weight of 406.5 g/mol (C20H26N2O5S).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08895547B2 |
|---|
| Source dataset | uspto-grants-2014_11 |
|---|
| ORD ID | ord-668d0254a0b149da8e99ea3121eb9915 |
|---|
| Source note | uspto-grants-2014_11 |
|---|
