Acetic Acid → HCID 68359187, compound

HRID 339902Notes

Reaction equation

HRID 339902 reaction equation
[OH:1][C:2]([CH3:21])([CH3:20])[CH:3]([C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[S:4]([NH2:7])(=[O:6])=[O:5].[C:22](OC)(OC)(OC)[O:23][CH3:24].C(O)(=O)C>O1CCOCC1>[CH3:22][O:23][C:24]1[O:1][C:2]([CH3:21])([CH3:20])[CH:3]([C:8]2[CH:9]=[CH:10][C:11]([N:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)=[CH:12][CH:13]=2)[S:4](=[O:5])(=[O:6])[N:7]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 74613Tetramethyl orthocarbonateHCID 68291730HCID 68291730, compound

Product 1

HCID 68359187HCID 68359187, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-Hydroxy-2-methyl-1-(4-morpholin-4-ylphenyl)propane-1-sulfonamide (41 mg) was stirred with tetramethyl orthocarbonate (0.2 ml), glacial acetic acid (0.01 ml) and dioxane (0.1 ml) at 90° C. for 4 hours. The solvents were removed under reduced pressure and the residue was used further without further purification.

Workup

  1. customThe solvents were removed under reduced pressure
  2. customthe residue was used further without further purification

Sources & evidence

ORD record
ord-52e9752026774f27baf95c6abb45da4d
Source dataset
uspto-grants-2014_11
Patent number
US08895547B2

Reaction notes

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