反应详情

Under inert gas, 10 g of 4-[(chlorosulfonyl)methyl]benzoic acid methyl ester were initially charged in 100 ml of DCM, then, at a temperature of 0° C., 12.1 ml of 2,4-dimethoxybenzylamine were added dropwise. The reaction mixture was filtered and the filtrate was washed with 1 N HCl. The organic phase was dried over MgSO4 and concentrated by rotary evaporation. This gave the product (14.2 g) with a molecular weight of 379.4 g/mol (C18H21NO6S).

1. filtrationThe reaction mixture was filtered
2. washthe filtrate was washed with 1 N HCl
3. dry with materialThe organic phase was dried over MgSO4
4. concentrationconcentrated by rotary evaporation