Tetramethyl orthocarbonate → HCID 68359229, compound

HRID 339908Notes

Reaction equation

HRID 339908 reaction equation
[OH:1][C:2]([CH3:22])([CH3:21])[CH:3]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[CH:10][CH:9]=1)[S:4]([NH2:7])(=[O:6])=[O:5].[C:23](OC)(OC)(OC)[O:24][CH3:25]>C(O)(=O)C>[CH3:23][O:24][C:25]1[O:1][C:2]([CH3:22])([CH3:21])[CH:3]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)=[CH:10][CH:9]=2)[S:4](=[O:5])(=[O:6])[N:7]=1

Participants

4

Reactant 2

HCID 74613Tetramethyl orthocarbonateHCID 68359227HCID 68359227, compound

Product 1

HCID 68359229HCID 68359229, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-Hydroxy-2-methyl-1-(4-morpholin-4-ylmethylphenyl)propane-1-sulfonamide (350 mg) was stirred with tetramethyl orthocarbonate (5 ml) and glacial acetic acid (1 ml) at 80° C. for 16 hours. The solvents were removed under reduced pressure and the residue was used further without further purification.

Workup

  1. customThe solvents were removed under reduced pressure
  2. customthe residue was used further without further purification

Sources & evidence

ORD record
ord-dbf6430348284991a92d3d515d7dc27f
Source dataset
uspto-grants-2014_11
Patent number
US08895547B2

Reaction notes

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