HCID 178418361, compound → HCID 178431664, compound

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Reaction Steps

To a solution of [(S)-3-(tert-butyldimethylsilanyloxy)-1-(2-fluorophenyl)propyl]-[5-(6-chloropyridin-3-yl)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda*6*-[1,4,3]oxathiazin-2-yl]amine (310 mg) in methanol was added palladium on charcoal (5%, 119 mg), and the mixture was stirred in a hydrogen atmosphere for 19 h. The mixture was filtered and the filtrate was concentrated. The residue was dissolved in methanol (10 ml) and treated with conc. HCl (1 ml). After 2 h, the solution was purified in a purification laboratory by means of preparative HPLC. This gave the product (108 mg) with a molecular weight of 407.5 g/mol (C19H22FN3O4S); MS (ESI): m/e=408 (M+H+).

Provenance & Evidence