反应详情

A solution of 3-(2-methoxy-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda*6*-[1,4,3]oxathiazin-5-yl)benzoic acid methyl ester (1.3 g) and (S)-1-(2-fluorophenyl)ethylamine (713 mg) in dichloromethane (15 ml) was stirred under an argon stream and thus concentrated. The residue was left to stand for 4 h, dissolved in ethyl acetate, washed with 1 M HCl and sodium bicarbonate solution, dried over magnesium sulfate and concentrated. This was followed by purification by column chromatography (ethyl acetate/heptane). This gave the product (1.2 g) with a molecular weight of 434.5 g/mol (C21H23FN2O5S).

1. concentrationthus concentrated
2. waitThe residue was left
3. dissolutiondissolved in ethyl acetate
4. washwashed with 1 M HCl and sodium bicarbonate solution
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated
7. customThis was followed by purification by column chromatography (ethyl acetate/heptane)