Water → 2-(4-formylphenyl)acetic Acid

HRID 339933Notes

Reaction equation

HRID 339933 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[OH2:13]>>[CH:2]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1)=[O:13]

Participants

3

Reactant 2

HCID 962WaterHCID 45190564-(Bromomethyl)phenylacetic acid

Product 1

HCID 113441872-(4-formylphenyl)acetic Acid

Procedure

[4-(Bromomethyl)phenyl]acetic acid (4.6 g) and cupric nitrate trihydrate (5 g) were suspended in water (50 mL) and heated at reflux for 1 hr. The solution was allowed to cool and the resulting white solid collected and washed with water to give the subtitle compound (2.06 g); MS multimode (+) 165

Workup

  1. temperatureheated
  2. temperatureat reflux for 1 hr
  3. temperatureto cool
  4. customthe resulting white solid collected
  5. washwashed with water

Sources & evidence

ORD record
ord-dde3cd1bc1064f949e894277c065fe41
Source dataset
uspto-grants-2014_11
Patent number
US08895570B2

Reaction notes

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