Thionyl Chloride → HCID 67989366, compound

Participants

Reaction Conditions

Reaction Steps

Methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-hydroxypropyl)amino]methyl}phenyl)acetate (described in WO2007/1031726, Example 1 step (ix)) (534 mg) was suspended in DCM (5 mL) and thionyl chloride (0.09 mL) added. The reaction mixture was stirred at 25° C. overnight. The reaction was concentrated in vacuo to give the subtitle product (0.55 g); MS multimode (+) 520

Provenance & Evidence