N-bromobutanimide → HCID 86681458, compound

Participants

Reaction Steps

To a solution of 2-{(2S)-3-(3-fluorophenyl)-2-[5-(1-methyl-1H-pyrazol-5-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]propyl}-1H-isoindole-1,3(2H)-dione (200.0 mg, 0.4044 mmol) [prepared in Example 1] in tetrahydrofuran (5 mL) was added N-bromosuccinimide (72.0 mg, 0.404 mmol). The solution was stirred at room temperature for 1 h and then concentrated under reduced pressure. The residue was purified by combi-flash chromatography eluted with EtOAc/hexane (50-100%). The purification afforded 231 mg (99.6% yield) of the desired product as white solid. LC/MS found: 573.0 (M+1)+.

Provenance & Evidence