Methanol → 2-[(1S)-2-amino-1-(cyclohexylmethyl)ethyl]-5-(1-methyl-1H-pyrazol-5-yl)isoindolin-1-one

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Reaction Conditions

Reaction Steps

A mixture of 2-{(2S)-3-cyclohexyl-2-[5-(1-methyl-1H-pyrazol-5-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]propyl}-1H-isoindole-1,3(2H)-dione (30 mg, 0.062 mmol) was dissolved in methanol (3 mL, 70 mmol) and hydrazine (0.3 mL, 10 mmol). The resulting mixture was stirred at 50° C. for 2 h. Direct purification on prep.—HPLC afforded 11 mg (50% yield) of the desired final product. LC-MS found: 353.1 (M+H)+.

Provenance & Evidence