Hydrazine → HCID 86681498, compound

Participants

Reaction Steps

2-{(2S)-3-Cyclopropyl-2-[5-(1-methyl-1H-pyrazol-5-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]propyl}-1H-isoindole-1,3(2H)-dione (56 mg, 0.13 mmol) was dissolved in hydrazine (1 mL, 30 mmol) and methanol (5 mL). The resulting solution was stirred at room temperature for 2 h. Direct purification on prep.HPLC afforded 15 mg (37% yield) of the final desired product. LC-MS found: 311 (M+H)+.

Provenance & Evidence