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HRID340012

反应详情

EQUATION

反应方程式

HRID 340012 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1ccsn1
HCID559224

Isothiazole-3-carboxylic acid

C4H3NO2S

结构：Br.Br.Br.CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCNC4)n[nH]c2c1
HCID178419240

未命名化合物

PRODUCTS

生成物

1
结构：CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccsn3)C4)n[nH]c2c1
HCID178436918

未命名化合物

收率 19.7%

PROCEDURE

实验过程

The title compound was prepared from 5-ethyl-2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-phenol trihydrobromide salt (Preparation 25, 50 mg, 80 μmol) and isothiazole-3-carboxylic acid (11 mg, 80 μmol) using the same method as described in Example 1. The crude material was purified by HPLC Method A to afford 7.7 mg of the title compound.

WORKUP

后处理

  1. customThe crude material was purified by HPLC Method A