HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Piperidin-1-yl)pyridine-3-carbaldehyde → HCID 178436908, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Piperidin-1-yl)pyridine-3-carbaldehyde | HCID 2763980 | — |
| Reactant | 5-Ethyl-2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazol[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-phenol trihydrobromide salt | HCID 178419240 | — |
| Product | HCID 178436908 | HCID 178436908 | 30.3% |
Reaction Steps
The title compound was prepared from 3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carbaldehyde (38 mg, 198 μmol) and 5-ethyl-2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-phenol trihydrobromide salt (Preparation 25, 50 mg, 132 μmol) using the method of Example 22. The crude material was purified by HPLC Method A to afford 22.1 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895544B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-d8e90c660a874aeba277ef28d5aad06d |
| Source note | uspto-grants-2014_11 |