HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Naphthyridine-2-carbaldehyde → HCID 178436903, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Naphthyridine-2-carbaldehyde | HCID 2050090 | — |
| Reactant | 5-Ethyl-2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazol[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-phenol trihydrobromide salt | HCID 178419240 | — |
| Product | HCID 178436903 | HCID 178436903 | 32.8% |
Reaction Steps
The title compound was prepared from [1,8]naphthyridine-2-carbaldehyde (31 mg, 198 μmol) and 5-ethyl-2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-phenol trihydrobromide salt (Preparation 25, 50 mg, 132 μmol) using the method of Example 22. The crude material was purified by HPLC Method B to afford 22.5 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895544B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-ede28c7077044026a797d0d98b1f3f0d |
| Source note | uspto-grants-2014_11 |