5-(Piperidin-1-yl)pyrazine-2-carboxylic acid → HCID 178464445, compound

Participants

Role	Name	HCID	Charge
Reactant	5-(Piperidin-1-yl)pyrazine-2-carboxylic acid	HCID 45789758	—
Reactant	2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-5-(2,2,2-trifluoro-ethyl)-phenol	HCID 178516038	—
Product	HCID 178464445	HCID 178464445	49.8%

Reaction Steps

The title compound was prepared from 5-piperidin-1-yl-pyrazine-2-carboxylic acid (Preparation 44, 35 mg, 168 μmol) and 2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-5-(2,2,2-trifluoro-ethyl)-phenol (Preparation 39, 100 mg, 168 μmol) using the method of Example 8. The crude material was purified by HPLC Method A to afford 29.0 mg of the title compound as the diethylamine salt.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08895544B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-c007570ac16e441d8561502bac0940e9
Source note	uspto-grants-2014_11