反应详情

To a solution of (4-fluoro-3-methoxy-phenyl)-methanol (10.0 g, 64.04 mmol) in MeCN (160 mL) was added a solution of NBS (11.4 g, 64.04 mmol) in MeCN (50 mL) and the resulting mixture was stirred at room temperature for 18 hours. The reaction mixture was concentrated in vacuo and the residue was suspended in diethyl ether (200 mL). Solid material was removed by filtration and washed with further diethyl ether. The filtrate was washed with water (200 mL) and brine (100 mL), dried over MgSO4 and concentrated in vacuo to give the title compound as a white solid (14.4 g) in a 96% yield.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customSolid material was removed by filtration
3. washwashed with further diethyl ether
4. washThe filtrate was washed with water (200 mL) and brine (100 mL)
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo