反应详情

Thionyl chloride (152 mL, 2.08 mol) was added dropwise at 20° C. to methanol (5 L). After the addition was completed, the mixture was stirred at this temperature for 30 minutes. Then 5-hydroxy-pyrazine-2-carboxylic acid (100 g, 714 mmol) was added, and the mixture was heated at reflux for 2 hours. The reaction mixture was concentrated in vacuo, and the residue was recrystallised from methanol (400 mL) to give 71 g (464 mmol) of the title compound in 65% yield.

1. additionAfter the addition
2. temperaturethe mixture was heated
3. temperatureat reflux for 2 hours
4. concentrationThe reaction mixture was concentrated in vacuo
5. customthe residue was recrystallised from methanol (400 mL)