참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Trimethylsilyl cyanide | HCID 82115 | — |
| 반응물 | 5-Bromo-2-methylpyridin-1-ium-1-olate | HCID 817164 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-Bromo-6-methylpyridine-2-carbonitrile | HCID 21952747 | — |
반응 단계
To a solution of 5-bromo-2-methylpyridine 1-oxide (from step 1) (1.0 eq.) in acetonitrile (0.2 M) was added trimethylsilyl cyanide (TMSCN) (4.0 eq.) and triethylamine (3.0 eq.). The reaction was heated at 100° C. overnight. After cooling to room temperature, the solvent was concentrated en vacuo, and the residue was purified by a COMBIFLASH® system (ISCO) using 0-50% ethyl acetate in hexane to give 3-bromo-6-methylpicolinonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08895577B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-6477f9285112491ea6713b42e0232879 |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
