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HRID 340260作成日：2026年10月25日

tert-Butyl (5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate → 2-((2,4-Dimethylphenyl)ethynyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine

https://huagongshe.com/reaction/340260

反応式

関与物質

役割名称HCID仕込み量
反応物tert-Butyl (5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamateHCID 46737997—
反応物3-Chloro-5-((2,4-dimethylphenyl)ethynyl)picolinonitrileHCID 66874361—
生成物2-((2,4-Dimethylphenyl)ethynyl)-8-methylbenzo[f][1,7]naphthyridin-5-amineHCID 66892550—

反応手順

2-((2,4-Dimethylphenyl)ethynyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine was prepared from 3-chloro-5-((2,4-dimethylphenyl)ethynyl)picolinonitrile (from Example 47/Step 3) and tert-butyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate (from Example 5/Step 2) following the procedures described for Example 44, step 4.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08895577B2
出典データセットuspto-grants-2014_11
ORD IDord-530545335b38466b9b120488eabcb362
出典メモuspto-grants-2014_11