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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 340296Generated: October 29, 2026

Triethyl phosphonoacetate → (E)-ethyl 3-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)acrylate

https://huagongshe.com/reaction/340296

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethyl phosphonoacetateHCID 13345—
Reactant5-Amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridine-8-carbaldehydeHCID 58166518—
Product(E)-ethyl 3-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)acrylateHCID 58213586—

Reaction Steps

(E)-ethyl 3-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)acrylate was prepared from 5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridine-8-carbaldehyde (from Example 69) and ethyl 2-(diethoxyphosphoryl)acetate (commercially available) following the procedures described for Example 65/Step 3. LRMS [M+H]=442.2

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08895577B2
Source datasetuspto-grants-2014_11
ORD IDord-6e519047487c49bdbfb449e82ad9db2e
Source noteuspto-grants-2014_11