Thionyl Chloride → HCID 86652358, compound

HRID 340334Notes

Reaction equation

HRID 340334 reaction equation
[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1.S(Cl)([Cl:31])=O>>[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18]([Cl:31])=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 58213539HCID 58213539, compound

Product 1

HCID 86652358HCID 86652358, compound

Procedure

A solution of 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylbenzoic acid (from the previous step) in thionyl chloride was stirred at 60° C. for 3 hour. After cooling to ambient temperature, the reaction mixture was concentrated en vacuo. The crude material was used for next step without purification.

Workup

  1. concentrationthe reaction mixture was concentrated en vacuo
  2. customThe crude material was used for next step without purification

Sources & evidence

ORD record
ord-611b483cfb9e44098db8337c0b78f391
Source dataset
uspto-grants-2014_11
Patent number
US08895577B2

Reaction notes

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