Acetic Acid → HCID 59797236, compound

HRID 34034Notes

Reaction equation

HRID 34034 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=3)=[N:7][N:8]2C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:4][C:3]=1[NH2:39].[C:40]([OH:43])(=O)[CH3:41]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=3)=[N:7][NH:8]2)=[CH:4][C:3]=1[NH:39][C:40](=[O:43])[CH3:41]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 68932237HCID 68932237, compound

Product 1

HCID 59797236HCID 59797236, compound

Procedure

525 mg of 6-fluoro-3-[(E)-2-(3-fluorophenyl)-vinyl]-1-trityl-1H-indazol-5-ylamine and 80 μl of glacial acetic acid were dehydraing-condensed in accordance with Example 127, followed by deprotection in the similar method as described in Example 16, to afford 150 mg of the title compound as bright yellow crystals.

Workup

  1. customdehydraing-condensed in accordance with Example 127

Sources & evidence

ORD record
ord-63b07e23401b4d93b02ac0c3d93b842e
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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