Water → HCID 59797368, compound

HRID 34042Notes

Reaction equation

HRID 34042 reaction equation
[CH3:1][O:2][C:3]1[C:11]([C:12]#[N:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:6][NH:7]2.[OH2:22]>S(=O)(=O)(O)O>[CH3:1][O:2][C:3]1[C:11]([C:12]([NH2:13])=[O:22])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:14]=[CH:15]/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:6][NH:7]2

Participants

4

Reactant 2

HCID 962WaterHCID 59797311HCID 59797311, compound

Product 1

HCID 59797368HCID 59797368, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
110 °C

Procedure

35 mg of 4-methoxy-3-(E)-styryl-1H-indazole-5-carbonitrile was dissolved in a mixed solvent 2 mL concentrated sulfuric acid/1 mL water, and stirred at 110° C. for 1 hour and 15 minutes. After cooling the reaction mixture on ice, water was slowly poured under ice cooling, and the precipitated crystals were collected by filtration, and washed with water. After drying under reduced pressure, 22 mg of the title compound was obtained as brown crude crystals.

Workup

  1. additionwas slowly poured under ice cooling
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customAfter drying under reduced pressure

Sources & evidence

ORD record
ord-08e09919d2a84b068666e3fd16037872
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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