反应详情

温度

110 °C

35 mg of 4-methoxy-3-(E)-styryl-1H-indazole-5-carbonitrile was dissolved in a mixed solvent 2 mL concentrated sulfuric acid/1 mL water, and stirred at 110° C. for 1 hour and 15 minutes. After cooling the reaction mixture on ice, water was slowly poured under ice cooling, and the precipitated crystals were collected by filtration, and washed with water. After drying under reduced pressure, 22 mg of the title compound was obtained as brown crude crystals.

1. additionwas slowly poured under ice cooling
2. filtrationthe precipitated crystals were collected by filtration
3. washwashed with water
4. customAfter drying under reduced pressure