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Trifluoroacetic acid → 6-Chloro-4-iodo-N-methylpyridin-3-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Tert-butyl (6-chloro-4-iodopyridin-3-yl)(methyl)carbamate | HCID 57443399 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-Chloro-4-iodo-N-methylpyridin-3-amine | HCID 57443400 | 97.7% |
反応手順
To the solution of tert-butyl (6-chloro-4-iodopyridin-3-yl)(methyl)carbamate (62.5 g, 0.172 mol) in 500 mL of anhydrous DCM was added 180 mL of TFA. Then the solution was stirred at room temperature for 4 hrs. Concentrated to remove the solvent, and purified by flash chromatography to afford 45.1 g 6-chloro-4-iodo-N-methylpyridin-3-amine as a yellow solid (Yield: 97.3%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895586B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-b2a4e43e580642f4b91b3a107698e91e |
| 出典メモ | uspto-grants-2014_11 |