Ethanol → CID 59797354

HRID 34044Notes

Reaction equation

HRID 34044 reaction equation
[CH3:1][O:2][C:3]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[N:6][NH:7]2.[CH2:15](O)[CH3:16]>O>[CH2:15]([O:13][C:12]([C:11]1[C:3]([O:2][CH3:1])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2)=[O:14])[CH3:16]

Participants

4

Reactant 2

HCID 702EthanolHCID 23070119CID 23070119

Product 1

HCID 59797354CID 59797354

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
95 °C

Procedure

2 g of 4-methoxy-1H-indazole-5-carboxylic acid was added to a mixed solvent of 40 mL ethanol/2.2 mL concentrated sulfuric acid, and stirred at 95° C. for 11 hours. After cooling the reaction solution on ice, water was slowly added under ice cooling, and the precipitated crystals were collected by filtration and washed with water. Thereafter, the crystals were dried under reduced pressure, to afford 1.52 g of the title compound as pale brown crude crystals.

Workup

  1. additionwas slowly added under ice cooling
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customThereafter, the crystals were dried under reduced pressure

Sources & evidence

ORD record
ord-29bbec0e7d9247aab261bd096818d609
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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