HCID 4183387, compound → 5-Methyl-6-(4-morpholinyl)-3-pyridinamine

HRID 340460Notes

Reaction equation

HRID 340460 reaction equation
[CH3:1][C:2]1[C:3]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[N:4][CH:5]=[C:6]([N+:8]([O-])=O)[CH:7]=1>[Pd].CO>[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[N:4][C:3]=1[N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1

Participants

4

Reactant 1

HCID 4183387HCID 4183387, compound

Product 1

HCID 592764965-Methyl-6-(4-morpholinyl)-3-pyridinamineYield 90.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A methanol (20 ml) solution containing 4-(3-methyl-5-nitropyridin-2-yl)morpholine (67 mg) was prepared and subjected to a hydrogenation reaction (room temperature; 1 bar; flow rate: 1 ml/min; 10% Pd/C) using H-cube™. Then, the solvent was distilled away under reduced pressure, and a purple solid of 5-methyl-6-morpholinopyridin-3-amine (52.4 mg) was thus obtained.

Workup

  1. customwas prepared
  2. distillationThen, the solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-0f62bd68746b4517a2f18575881d5b08
Source dataset
uspto-grants-2014_11
Patent number
US08895585B2

Reaction notes

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