HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-nitro-3-(1H-pyrazol-1-yl)quinoline → 3-(1H-pyrazol-1-yl)quinolin-7-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-nitro-3-(1H-pyrazol-1-yl)quinoline | HCID 68618824 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(1H-pyrazol-1-yl)quinolin-7-amine | HCID 86683863 | 63.5% |
Reaction Steps
A methanol (10 ml) solution containing 7-nitro-3-(1H-pyrazol-1-yl)quinoline (36 mg) was prepared and subjected to a hydrogenation reaction (80° C.; 50 bar; flow rate: 1 ml/min; 10% Pd/C) using H-cube™. Thereafter, the solvent was distilled away under reduced pressure, and a purple solid of 3-(1H-pyrazol-1-yl)quinolin-7-amine (20 mg) was thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895585B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-0ea0fd17a6bc4c6eb3e0e5ff5de7e47a |
| Source note | uspto-grants-2014_11 |