反应详情

Sodium borohydride (3.7 g) was added in divided portions to a methanol/isopropanol (30 ml/30 ml) solution containing (S)-tert-butyl(3-oxohexan-2-yl)carbamate (17.5 g) at room temperature, followed by stirring for 1 hour. The solvent was distilled away under reduced pressure, and water was added, followed by extraction with ethyl acetate. The obtained organic layer was washed with saturated saline and dried over anhydrous sodium sulfate, the solvent was distilled away under reduced pressure, and a white solid of tert-butyl((2S)-3-hydroxyhexan-2-yl)carbamate (17 g) was obtained.

1. distillationThe solvent was distilled away under reduced pressure, and water
2. additionwas added
3. extractionfollowed by extraction with ethyl acetate
4. washThe obtained organic layer was washed with saturated saline
5. dry with materialdried over anhydrous sodium sulfate
6. distillationthe solvent was distilled away under reduced pressure