tert-Butyl carbazate → HCID 68934180, compound

HRID 34053Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4](/[CH:8]=[CH:9]/[C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:21](O)=[O:22])[C:17]=3[O:19][CH3:20])[N:12]([C:24]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:11]=2)[CH:5]=[CH:6][CH:7]=1.[C:43]([O:47][C:48]([NH:50][NH2:51])=[O:49])([CH3:46])([CH3:45])[CH3:44]>>[C:43]([O:47][C:48]([NH:50][NH:51][C:21]([C:16]1[C:17]([O:19][CH3:20])=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]([C:24]([C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[N:11]=[C:10]2/[CH:9]=[CH:8]/[C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)=[O:22])=[O:49])([CH3:46])([CH3:45])[CH3:44]

Participants

Reactant 2

HCID 70091tert-Butyl carbazate

HCID 689310823-[(E)-2-(3-fluorophenyl)-vinyl]-4-methoxy-1-trityl-1H-indazole-5-carboxylic acid

Product 1

HCID 68934180HCID 68934180, compoundYield 112%

Procedure

94 mg of 3-[(E)-2-(3-fluorophenyl)-vinyl]-4-methoxy-1-trityl-1H-indazole-5-carboxylic acid and 34.4 mg of hydrazine carboxylic acid tert-butyl ester were condensed in the manner as described in Example 127, to afford 126.9 mg of the title compound as pale yellow crude crystals.

Workup

customcondensed in the manner

Sources & evidence

ORD record: ord-5bf5f345cacb46b0977ef51861d239d9
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429609B2

Reaction notes

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