HRID34053

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70091

Hydrazinecarboxylic acid, 1,1-dimethylethyl ester

C5H12N2O2

结构：COc1c(C(=O)O)ccc2c1c(/C=C/c1cccc(F)c1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1

HCID68931082

未命名化合物

PRODUCTS

生成物

结构：COc1c(C(=O)NNC(=O)OC(C)(C)C)ccc2c1c(/C=C/c1cccc(F)c1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1

HCID68934180

未命名化合物

收率 112%

PROCEDURE

实验过程

94 mg of 3-[(E)-2-(3-fluorophenyl)-vinyl]-4-methoxy-1-trityl-1H-indazole-5-carboxylic acid and 34.4 mg of hydrazine carboxylic acid tert-butyl ester were condensed in the manner as described in Example 127, to afford 126.9 mg of the title compound as pale yellow crude crystals.

WORKUP

后处理

customcondensed in the manner

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5bf5f345cacb46b0977ef51861d239d9
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07429609B2
来源说明: uspto-grants-2008_09

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4](/[CH:8]=[CH:9]/[C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:21](O)=[O:22])[C:17]=3[O:19][CH3:20])[N:12]([C:24]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:11]=2)[CH:5]=[CH:6][CH:7]=1.[C:43]([O:47][C:48]([NH:50][NH2:51])=[O:49])([CH3:46])([CH3:45])[CH3:44]>>[C:43]([O:47][C:48]([NH:50][NH:51][C:21]([C:16]1[C:17]([O:19][CH3:20])=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]([C:24]([C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[N:11]=[C:10]2/[CH:9]=[CH:8]/[C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)=[O:22])=[O:49])([CH3:46])([CH3:45])[CH3:44]