1-Cyclohexenylboronic acid → 2-Cyclohex-1-enyl-4-(1,1-dioxo-1lambda6-[1,2,6]thiadiazinan-4-yl)-phenylamine

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Reaction Steps

2-Bromo-4-(1,1-dioxo-1λ6-[1,2,6]thiadiazinan-4-yl)-phenylamine (as prepared in the previous step, 46.9 mg, 0.153 mmol) was reacted with cyclohexane-1-enyl boronic acid (24.1 mg, 0.191 mmol) according to the Suzuki coupling procedure of Example 4, step (e) and purified on silica (20-100% EtOAc-hexane) to afford the title compound (30.7 mg, 65%): Mass spectrum (ESI, m/z): Calcd. for C15H21N3O2S, 308.1 (M+H). found 308.1.

Provenance & Evidence