4-(2,6-Diethyl-1,1-dioxo-1lambda6-[1,2,6]thiadiazinan-4-yl)-2-(4-methyl-piperidin-1-yl)-phenylamine → HCID 178462491, compound

HRID 340584Notes

Reaction equation

HRID 340584 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([N:16]3[CH2:21][CH2:20][CH:19]([CH3:22])[CH2:18][CH2:17]3)[CH:10]=2)[CH2:6][N:5]([CH2:23][CH3:24])[S:4]1(=[O:26])=[O:25])[CH3:2].[K+].[CH3:28][C:29]1[N:33](COCC[Si](C)(C)C)[C:32]([C:42]([O-])=[O:43])=[N:31][CH:30]=1>>[CH2:23]([N:5]1[CH2:6][CH:7]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:42]([C:32]3[NH:31][CH:30]=[C:29]([CH3:28])[N:33]=3)=[O:43])=[C:11]([N:16]3[CH2:17][CH2:18][CH:19]([CH3:22])[CH2:20][CH2:21]3)[CH:10]=2)[CH2:8][N:3]([CH2:1][CH3:2])[S:4]1(=[O:26])=[O:25])[CH3:24]

Participants

3

Reactant 2

HCID 597711574-(2,6-Diethyl-1,1-dioxo-1lambda6-[1,2,6]thiadiazinan-4-yl)-2-(4-methyl-piperidin-1-yl)-phenylamineHCID 597712535-Methyl-1-(2-trimethylsilanyl-ethoxymethyl)-1h-imidazole-2-carboxylic acid potassium salt

Product 1

HCID 178462491HCID 178462491, compound

Procedure

The title compound is prepared from 4-(2,6-diethyl-1,1-dioxo-1λ6-[1,2,6]thiadiazinan-4-yl)-2-(4-methyl-piperidin-1-yl)-phenylamine (as prepared in the previous step) and 5-methyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid potassium salt (as prepared above in this example, step (c)) following the procedure of Example 11, steps (d)-(e).

Sources & evidence

ORD record
ord-a5d997e7e30d4878a4baa8a0f74d5faf
Source dataset
uspto-grants-2014_11
Patent number
US08895584B2

Reaction notes

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