HCID 66697772, compound → HCID 86664253, compound

Participants

Reaction Conditions

Reaction Steps

{5-[(4-Fluorophenyl)sulfonyl]-1-(2-fluoropyridin-3-yl)-1H-pyrazol-3-yl}methanol (135 mg) was dissolved in toluene (2 mL), manganese dioxide (167 mg) was added, and the mixture was stirred at 100° C. for 42 hr. The reaction mixture was allowed to cool to room temperature, and filtered through celite. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent:hexane-ethyl acetate=19:1→3:1) to give the title compound as a colorless oil (yield 108 mg, yield 80%).

Provenance & Evidence