Hydrochloric Acid → HCID 66697803, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 1-(2-fluoropyridin-3-yl)-5-[(3-methylphenyl)sulfonyl]-1H-pyrazole-3-carboxylate (384 mg) in tetrahydrofuran (5 mL) was cooled to −78° C., a 1.5 mol/L solution (2.6 mL) of diisobutylaluminum hydride in toluene was added dropwise. The reaction mixture was stirred for 1 hr at 0° C., treated with 1 mol/L hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with water, saturated aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound as a colorless oil (yield 320 mg, yield 94%)

Provenance & Evidence