HCID 66697803, compound → HCID 86664254, compound

Participants

Reaction Conditions

Reaction Steps

{1-(2-Fluoropyridin-3-yl)-5-[(3-methylphenyl)sulfonyl]-1H-pyrazol-3-yl}methanol (320 mg) was dissolved in toluene (5 mL), manganese dioxide (802 mg) was added, and the mixture was stirred at 90° C. for 4 hr. The reaction mixture was allowed to cool to room temperature, and filtered through celite. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent:hexane-ethyl acetate=9:1→2:1) to give the title compound as a colorless oil (yield 266 mg, yield 83%).

Provenance & Evidence