Hydrogen chloride-ethyl acetate → HCID 66697831, compound

Participants

Reaction Steps

tert-Butyl({5-[(3-cyanophenyl)sulfonyl]-1-(2-fluoropyridin-3-yl)-1H-pyrazol-3-yl}methyl)methylcarbamate (247 mg) was dissolved in ethyl acetate (2 mL) and 2-propanol (1 mL), and 4 mol/L hydrogen chloride-ethyl acetate solution (3 mL) was added. After stirring at room temperature for 3 hr, the reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from a mixed solvent of ethanol and water to give the title compound as colorless crystals (yield 184 mg, yield 86%). melting point 237-240° C.

Provenance & Evidence