4-Bromo-7-hydroxy-6-nitro-2,3-dihydro-1H-inden-1-one → 6-Amino-7-hydroxy-2,3-dihydro-1H-inden-1-one hydrobromide

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Reaction Steps

4-Bromo-7-hydroxy-6-nitroindan-1-one (2.90 g, 10.66 mmol) was dissolved in methanol (53 mL), a 10% palladium-carbon powder (290 mg) was added, and the mixture was stirred at room temperature for 6 hr under a hydrogen atmosphere. The catalyst was filtered off using celite, and the filtrate was concentrated under reduced pressure to give the title compound (2.08 g, yield 80%).

Provenance & Evidence