反应详情

1-Indanone (5.00 g, 37.8 mmol) was dissolved in sulfuric acid (40 mL), and thereto was added dropwise a solution of potassium nitrate (3.83 g, 37.8 mmol) in sulfuric acid (10 mL) under ice-cooling. The mixture was stirred for 1 hr under ice-cooling, ice was added to the reaction solution, and the mixture was stirred at room temperature overnight. The precipitated solid was collected by filtration, and purified by silica gel column chromatography (ethyl acetate/hexane=15/85→45/55) to give the title compound (4.01 g, yield 60%).

1. temperaturecooling
2. temperaturecooling
3. additionice was added to the reaction solution
4. stirringthe mixture was stirred at room temperature overnight
5. filtrationThe precipitated solid was collected by filtration
6. custompurified by silica gel column chromatography (ethyl acetate/hexane=15/85→45/55)