Methyl iodide → HCID 57481469, compound

Participants

Reaction Steps

Iodomethane (2 Min methyl-tert-butyl ether, 22.87 mL, 45.7 mmol) was added to a solution of cesium carbonate (14.9 g, 45.7 mmol) and 1-(biphenyl-4-ylmethyl)-4,6-difluoro-5-iodo-1,3-dihydro-2H-benzimidazole-2-thione (10.94 g, 22.87 mmol) in THF (100 mL). After stirring the reaction at rt overnight, the volatiles were removed. Chromatography of the resulting residue over silica eluting with 15-60% EtOAc/hexanes afforded the desired product as a beige solid.

Provenance & Evidence