Acetic Acid → HCID 178524021, compound

HRID 34079Notes

Reaction equation

HRID 34079 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]1[C:12]2[CH:18]=C(C#N)[S:16][C:13]=2[NH:14][N:15]=1.S(=O)(=O)(O)O.[C:26]([OH:29])(=[O:28])[CH3:27]>O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]1[C:12]2[CH:18]=[C:27]([C:26]([OH:29])=[O:28])[S:16][C:13]=2[NH:14][N:15]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 178509371HCID 178509371, compound

Product 1

HCID 178524021HCID 178524021, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of 33 mg of 3-(naphthalen-2-yl)-1H-thieno[2,3-c]pyrazole-5-carbonitrile in 1.0 mL of acetic acid and 0.3 mL of water was added 0.3 mL of concentrated sulfuric acid at room temperature and stirred at 110° C. for a day. After cooling the solution to room temperature, 10 mL of ice water was added, and the precipitated crystals were collected by filtration and washed with water, to afford 33 mg of the title compound as pale brown crystals.

Workup

  1. temperatureAfter cooling the solution to room temperature
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-c354e435240f444c91e51ece1fe45ee2
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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