反应详情

温度

110 °C

To a solution of 33 mg of 3-(naphthalen-2-yl)-1H-thieno[2,3-c]pyrazole-5-carbonitrile in 1.0 mL of acetic acid and 0.3 mL of water was added 0.3 mL of concentrated sulfuric acid at room temperature and stirred at 110° C. for a day. After cooling the solution to room temperature, 10 mL of ice water was added, and the precipitated crystals were collected by filtration and washed with water, to afford 33 mg of the title compound as pale brown crystals.

1. temperatureAfter cooling the solution to room temperature
2. filtrationthe precipitated crystals were collected by filtration
3. washwashed with water