Ethanone, 1-(1H-pyrazolo[4,3-c]pyridin-1-yl)- → 1H-Pyrazolo[4,3-c]pyridine

HRID 34082Notes

Reaction equation

HRID 34082 reaction equation
[N:1]1(C(=O)C)[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1>C(O)C.[OH-].[Na+]>[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1

Participants

4

Reactant 1

HCID 23070130Ethanone, 1-(1H-pyrazolo[4,3-c]pyridin-1-yl)-

Product 1

HCID 199305001H-Pyrazolo[4,3-c]pyridineYield 81.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

To a solution of 6.44 g of 1-pyrazolo[4,3-c]pyridin-1-yl-ethanone in 120 mL of ethanol, 10 mL of 5N sodium hydroxide aqueous solution was added at room temperature and stirred at this temperature for 30 minutes. After neutralization with 5N hydrochloric acid, the solvent was evaporated, the residue was washed with ethyl acetate, and the solvent of filtrate was evaporated, to afford 3.88 g of the title compound as pale yellow crystals.

Workup

  1. customAfter neutralization with 5N hydrochloric acid, the solvent was evaporated
  2. washthe residue was washed with ethyl acetate
  3. customthe solvent of filtrate was evaporated

Sources & evidence

ORD record
ord-bc9584153d024b7d907f9748370ecf08
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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