HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → 3-Phenylisoxazole-5-carbonyl azide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Phenylisoxazole-5-carboxylic Acid | HCID 737474 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Phenylisoxazole-5-carbonyl azide | HCID 57947621 | 60.7% |
Reaction Steps
To a solution of 3-phenylisoxazole-5-carboxylic acid (1.0 g, 5 mmol, 1.0 equiv.) in DMF (20 mL) and THF (20 mL), was added HBTU (2.28 g, 6 mmol, 1.2 equiv.), followed by sodium azide (0.65 g, 10 mmol, 2.0 equiv.) and DIEA (2.6 mL, 15 mmol, 3.0 equiv.). The mixture was stirred at RT for 30 min, concentrated, followed by adding of H2O (40 mL). The precipitate was filtered, washed with H2O, and dried in vacuo to give 3-phenylisoxazole-5-carbonyl azide (0.65 g, 60%). LRMS (M−18+H+) m/z 187.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895582B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-d765724bad644494a717e7a45024b3ee |
| Source note | uspto-grants-2014_11 |