Tetrahydrofuran → (S)-1-(1-(tert-butyldimethylsilyloxy)pent-4-en-2-yl)-3-(2,3-difluorobenzyl)-1-methylurea

HRID 340962Notes

Reaction equation

HRID 340962 reaction equation
[CH:1]1[C:6]([N+:7]([O-])=O)=[CH:5][CH:4]=[C:3]([Cl-]C([O-])=O)C=1.[F:14][C:15]1[C:22]([F:23])=[CH:21][CH:20]=[CH:19][C:16]=1[CH2:17][NH2:18].[CH3:24]CN(C(C)C)C(C)C.[Si:33]([O:40]C[C@@H](NC)CC=C)([C:36]([CH3:39])([CH3:38])[CH3:37])([CH3:35])[CH3:34].C1C[O:51][CH2:50]C1>>[Si:33]([O:40][CH2:1][C@@H:6]([N:7]([CH3:24])[C:50]([NH:18][CH2:17][C:16]1[CH:19]=[CH:20][CH:21]=[C:22]([F:23])[C:15]=1[F:14])=[O:51])[CH2:5][CH:4]=[CH2:3])([C:36]([CH3:37])([CH3:38])[CH3:39])([CH3:34])[CH3:35]

Participants

5

Reactant 4

HCID 8028Tetrahydrofuran3×HCID 81531DiisopropylethylamineHCID 27369412,3-DifluorobenzylamineHCID 57947450(S)-1-(tert-butyldimethylsilyloxy)-N-methylpent-4-en-2-amine

Product 1

HCID 57947466(S)-1-(1-(tert-butyldimethylsilyloxy)pent-4-en-2-yl)-3-(2,3-difluorobenzyl)-1-methylureaYield 49%

Procedure

To a solution of 4-nitrophenylchloroformate (7.04 g, 34.9 mmol) in THF (100 mL) was added a solution of 2,3-difluorobenzylamine (4.26 mL, 36.4 mmol) and DIEA (13.2 mL, 75.9 mmol) in THF (20 mL). The resulting solution was stirred at RT for 20 min. The reaction solution was added into a solution of (S)-1-(tert-butyldimethylsilyloxy)-N-methylpent-4-en-2-amine (31.9 mmol) in THF (50 mL). The resulting solution was stirred at RT overnight. The solvent was removed and the resulting residue was re-dissolved in EtOAc (500 mL). The organic mixture was washed with NaOH (1 N, 100 mL×3), HCl (0.5 N, 100 mL), saturated NaHCO3, and brine, dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified on silica gel column using a mixture of DCM and MeOH to give (S)-1-(1-(tert-butyldimethylsilyloxy)pent-4-en-2-yl)-3-(2,3-difluorobenzyl)-1-methylurea (6.8 g, 49%) as a white solid. LRMS (M+H+) m/z 399.2.

Workup

  1. stirringThe resulting solution was stirred at RT overnight
  2. customThe solvent was removed
  3. dissolutionthe resulting residue was re-dissolved in EtOAc (500 mL)
  4. washThe organic mixture was washed with NaOH (1 N, 100 mL×3), HCl (0.5 N, 100 mL), saturated NaHCO3, and brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was purified on silica gel column
  9. additiona mixture of DCM and MeOH

Sources & evidence

ORD record
ord-46bc24d32ae44684a88d5e84b118a5d1
Source dataset
uspto-grants-2014_11
Patent number
US08895582B2

Reaction notes

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