HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34102Generated: October 29, 2026
HCID 178468689, compound → 4-(3-amino-3-oxopropoxy)-3-[(E)-2-(4-fluorophenyl)ethenyl]-1H-indazole-5-carboxylic acid
https://huagongshe.com/reaction/34102
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 178468689 | HCID 178468689 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 4-(3-amino-3-oxopropoxy)-3-[(E)-2-(4-fluorophenyl)ethenyl]-1H-indazole-5-carboxylic acid | HCID 60035013 | 55.1% |
Reaction Steps
85.3 mg of 4-(2-carbamoylethoxy)-3-[(E)-2-(4-fluorophenyl)-vinyl]-1H-indazole-5-carboxylic acid ethyl ester obtained by Example 763 was dissolved in 3 mL of concentrated sulfuric acid, stirred at 35° C. for 16 hours, and then added with ice under ice cooling. The precipitated crystals were collected by filtration, washed with water, and then dried under reduced pressure, to afford 43.7 mg of the title compound as yellow crude crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07429609B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-c07f796ab20845708b68186787d34af2 |
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| Source note | uspto-grants-2008_09 |
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