HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-Bromo-3-fluoropyridine-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Bromo-3-fluoropyridine-2-carboxylic acid | HCID 21075872 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-3-fluoropyridine-2-carbonyl chloride | HCID 86668675 | — |
Reaction Steps
5-Bromo-3-fluoropyridine-2-carboxylic acid (0.40 g, 1.8 mmol) was dissolved in dichloromethane (8 mL), treated with thionyl chloride (0.80 mL, 11 mmol, 6 equiv) and the mixture was placed into a preheated oil bath at 45° C. for 3 hours. The mixture was concentrated in vacuo, providing the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895580B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-a6b4a0336c6f4443a596bf37f355a251 |
| Source note | uspto-grants-2014_11 |