反应详情

温度

-78 °C

Ethyl 2-oxo-1-phenylpiperidine-4-carboxylate (0.31 g, 1.3 mmol) was dissolved in tetrahydrofuran (10 mL), cooled to −78° C. and treated with lithium aluminum hydride (0.16 mL, 2 M tetrahydrofuran solution, 3.8 mmol, 3 equiv). The mixture was warmed to −40° C., stirred for 1 hour and treated with ammonium chloride (50 mL, aqueous saturated). The aqueous layer was extracted with ethyl acetate (2×50 mL) and the combined organic extracts were dried with sodium sulfate, filtered and concentrated in vacuo, providing the titled compound.

1. temperatureThe mixture was warmed to −40° C.
2. extractionThe aqueous layer was extracted with ethyl acetate (2×50 mL)
3. dry with materialthe combined organic extracts were dried with sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo