HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-[(E)-2-(4-fluorophenyl)ethenyl]-N-[1-(2-hydroxyethyl)cyclopropyl]-4-methoxy-1H-indazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Trimethylsilyl iodide | HCID 85247 | — |
| Reactant | HCID 86600699 | HCID 86600699 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[(E)-2-(4-fluorophenyl)ethenyl]-N-[1-(2-hydroxyethyl)cyclopropyl]-4-methoxy-1H-indazole-5-carboxamide | HCID 60034883 | — |
Reaction Steps
20 mg of 3-[(E)-2-(4-fluorophenyl)-vinyl]-4-methoxy-1H-indazole-5-carboxylic acid (1-benzyloxyethyl-cyclopropyl)-amide obtained by Example 814 was dissolved in 1 mL of dichloromethane, added with 6.4 μl of trimethylsilyliodide at 0° C. under nitrogen atmosphere, and stirred at this temperature for 2 hours. The reaction solution was added with methanol to stop the reaction, and the solvent was concentrated, followed by purification by LC-MS, to afford 1.7 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429609B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-f07ad732874947a08d3fcb2c79667574 |
| Source note | uspto-grants-2008_09 |