HCID 68153800, compound → HCID 69935042, compound

Participants

Reaction Steps

2-Allyl-5-(4-fluorobenzyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one (Example 764, 20 mg, 0.060 mmol) was dissolved in methanol (3 mL), treated with palladium on carbon (2 mg, 10 wt % on activated carbon, 0.1 wt equiv) sparged under an atmosphere of hydrogen (1 atm) and stirred for 4 hours at ambient temperature. The mixture was sparged under an atmosphere of nitrogen, filtered through a pad of Celite and the filtrate was concentrated in vacuo, providing the titled compound: 1H-NMR (400 MHz, CD3OD) δ 9.07 (1H, s), 8.42 (1H, d, J=7.7 Hz), 7.96 (1H, d, J=8.5 Hz), 7.78-7.68 (2H, m), 7.38-7.37 (2H, m), 7.16-7.11 (2H, m), 5.85 (2H, s), 4.10 (2H, t, J=7.0 Hz), 1.95-1.89 (2H, m), 0.99 (3H, t, J=7.5 Hz), ppm; low resolution mass spectrometry (ES+) m/z 336.0 [(M+H)+; calculated for C20H18FN3O: 336.1].

Provenance & Evidence