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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34111Generated: October 25, 2026

Hydrazine hydrate (1:1) → 2-(Piperidin-1-yl)acetohydrazide

https://huagongshe.com/reaction/34111

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrazine hydrate (1:1)HCID 24654—
Reactant1-Piperidineacetic acid, ethyl esterHCID 643466—
SolventEthanolHCID 702—
Product2-(Piperidin-1-yl)acetohydrazideHCID 6421769—

Reaction Conditions

Temperature70 °C

Reaction Steps

3.86 g of piperidin-1-yl-acetic acid ethyl ester was dissolved in 40 mL of ethanol, added with 3.39 mL of hydrazine monohydrate, and stirred at 70° C. for 5 hours. After allowing the solution to cool to room temperature, the solvent was evaporated, to afford 3.8 g of the title compound as pale yellow crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429609B2
Source datasetuspto-grants-2008_09
ORD IDord-c7ae76d9cb824d00b70c01074d2b137b
Source noteuspto-grants-2008_09