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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 341152Generated: October 31, 2026

Hydrochloric Acid → Rx-01_423 hydrochloride

https://huagongshe.com/reaction/341152

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant(5S)-{4'-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2'-fluoro-biphenyl-4-ylmethyl}-(3-fluoro-propyl)-carbamic acid tert-butyl esterHCID 68540787—
Solvent1,4-DioxaneHCID 31275—
ProductRx-01_423 hydrochlorideHCID 11293964—

Reaction Steps

BOC-protected amine 121 was subsequently treated with 4 N hydrogen chloride in 1,4-dioxane as in Example 1 to afford compound 11. The product obtained from this process was identical by NMR and LCMS to the material obtained in Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08895741B2
Source datasetuspto-grants-2014_11
ORD IDord-d66c8cc60bf24415884c8062240c20f9
Source noteuspto-grants-2014_11