Hydrogen chloride-ethyl acetate → HCID 68595181, compound

HRID 341176Notes

Reaction equation

HRID 341176 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]3[C:16]([C:19]4[CH:20]=[C:21]([NH:25][C:26]([NH:28][CH2:29][CH3:30])=[O:27])[CH:22]=[CH:23][CH:24]=4)=[CH:17][N:18]=[C:12]3[CH:11]=2)[CH:7]=[CH:8][CH:9]=1.CCOC(C)=O.[ClH:37]>CCO>[ClH:37].[ClH:37].[NH2:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]3[C:16]([C:19]4[CH:20]=[C:21]([NH:25][C:26]([NH:28][CH2:29][CH3:30])=[O:27])[CH:22]=[CH:23][CH:24]=4)=[CH:17][N:18]=[C:12]3[CH:11]=2)[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 44177765HCID 44177765, compound

Product 1

HCID 68595181HCID 68595181, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 1-(3-{7-[3-(2-Amino-ethyl)-phenyl]-imidazo[1,2-a]pyridin-3-yl}-phenyl)-3-ethyl-urea (0.01 g) in EtOH (2 ml) was treated with saturated EtOAc/HCl. The reaction was stirred until all in solution, then concentrated under reduced pressure, and the residue triturated with ether and dried to give (0.007 g) of the product MS: [M+H]+ 400

Workup

  1. concentrationconcentrated under reduced pressure
  2. customthe residue triturated with ether
  3. customdried

Sources & evidence

ORD record
ord-cf9582747119404b95504e2bc1cbdd86
Source dataset
uspto-grants-2014_11
Patent number
US08895745B2

Reaction notes

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